"Are you dating anybody?" a caller named Nancy asked. "I think you're wonderful, original and I love you."
"Aww. Thank you, Nancy," Arquette said. "I am, I'm dating an amazing girl named Christina McClarty. I'm madly in love with her and she's the love of my life. Absolutely."
"Wow, she's the love of your life?" Cohen, seeming a little taken aback, asked to clarify.
"Absolutely," the actor said. "She's my girl. She's got my back."
Arquette began dating the Entertainment Tonight reporter two years ago, but briefly split in March 2012. The Scream star shares daughter Coco, 9, with Cox, 49, and told ABC News on Oct. 2 that he's still friends with his ex.
"It really was a goal of ours to not make it a fight, to really support each other and although we'd grown apart to stay connected, to stay friends, to still love each other," he explained. "I still obviously feel so blessed that I met her and that we have a child together and that she's in my life. She's still one of my closest, greatest friends."